@article {106,
	title = {Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue.},
	journal = {Science (New York, N.Y.)},
	volume = {294},
	year = {2001},
	month = {2001 Dec 21},
	pages = {2542-5},
	abstract = {Stem cells generate many differentiated, short-lived cell types, such as blood, skin, and sperm, throughout adult life. Stem cells maintain a long-term capacity to divide, producing daughter cells that either self-renew or initiate differentiation. Although the surrounding microenvironment or "niche" influences stem cell fate decisions, few signals that emanate from the niche to specify stem cell self-renewal have been identified. Here we demonstrate that the apical hub cells in the Drosophila testis act as a cellular niche that supports stem cell self-renewal. Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance of the germ line stem cell population.},
	keywords = {Animals, Cell Differentiation, Cell Division, Cell Lineage, Cues, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Germ Cells, Glycoproteins, Janus Kinases, Ligands, Male, Mutation, Protein-Tyrosine Kinases, Signal Transduction, Spermatocytes, Spermatogenesis, STAT Transcription Factors, Stem Cells, Testis, Trans-Activators, Transcription Factors},
	issn = {0036-8075},
	doi = {10.1126/science.1066707},
	author = {Kiger, A A and Jones, D L and Schulz, C and Rogers, M B and Fuller, M T}
}
