@article {119,
	title = {Dual activation of the Drosophila toll pathway by two pattern recognition receptors.},
	journal = {Science (New York, N.Y.)},
	volume = {302},
	year = {2003},
	month = {2003 Dec 19},
	pages = {2126-30},
	abstract = {The Toll-dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 (GNBP1) gene and leads to compromised survival of mutant flies after Gram-positive infections, but not after fungal or Gram-negative bacterial challenge. Our results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway. The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects.},
	keywords = {Animals, Carrier Proteins, DNA Transposable Elements, Drosophila, Drosophila Proteins, Gene Expression, Genes, Insect, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, Hypocreales, Insect Proteins, Mutation, Phenotype, Receptors, Cell Surface, Serine Endopeptidases, Toll-Like Receptors},
	issn = {1095-9203},
	doi = {10.1126/science.1085432},
	author = {Gobert, Vanessa and Gottar, Marie and Matskevich, Alexey A and Rutschmann, Sophie and Royet, Julien and Belvin, Marcia and Hoffmann, Jules A and Ferrandon, Dominique}
}
