@article {123,
	title = {Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.},
	journal = {Nature immunology},
	volume = {5},
	year = {2004},
	month = {2004 Nov},
	pages = {1175-80},
	abstract = {The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of-function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex.},
	keywords = {Animals, Carrier Proteins, Drosophila, Drosophila Proteins, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Mutation, Mycoses, Receptors, Cell Surface, Staphylococcus aureus, Toll-Like Receptors},
	issn = {1529-2908},
	doi = {10.1038/ni1123},
	author = {Bischoff, Vincent and Vignal, C{\'e}cile and Boneca, Ivo G and Michel, Tatiana and Hoffmann, Jules A and Royet, Julien}
}
