@article {143,
	title = {Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling.},
	journal = {Trends in cell biology},
	volume = {20},
	year = {2010},
	month = {2010 May},
	pages = {287-98},
	abstract = {The Hedgehog signalling pathway controls numerous developmental processes. In response to Hedgehog, Smoothened (Smo), a seven-pass transmembrane protein, orchestrates pathway signalling and controls transcription factor activation. In the absence of Hedgehog, the receptor Patched indirectly inhibits Smo in a catalytic manner. Many questions surrounding Smo activation and signalling remain. Recent findings in Drosophila and vertebrate systems have provided strong evidence that Smo acts as a G-protein-coupled receptor. We discuss the role and regulation of Smo and reassess similarities between Smo and G-protein-coupled receptors. We also examine recently identified members of the invertebrate and vertebrate Smo signalling cascades that are typical components of G-protein-coupled receptor pathways. Greater understanding of the mechanisms of Smo activation and its signalling pathways will allow implementation of novel strategies to target disorders related to disruption of Hh signalling.},
	keywords = {Animals, Drosophila Proteins, Hedgehog Proteins, Humans, Models, Biological, Phosphorylation, Protein Binding, Receptors, G-Protein-Coupled, Signal Transduction},
	issn = {1879-3088},
	doi = {10.1016/j.tcb.2010.02.002},
	author = {Ayers, Katie L and Th{\'e}rond, Pascal P}
}
