@article {149,
	title = {Toll signaling pathways in the innate immune response.},
	journal = {Current opinion in immunology},
	volume = {12},
	year = {2000},
	month = {2000 Feb},
	pages = {13-9},
	abstract = {The Toll signaling pathway, which is required for the establishment of the dorsal-ventral axis in Drosophila embryos, plays an important role in the response of larval and adult Drosophila to microbial infections. Recent genetic evidence has shown that a mammalian Toll-like receptor, mouse Tlr4, is the signal transducing receptor activated by bacterial lipopolysaccharide. Thus, Toll-like receptors appear to detect a variety of microbial components and to trigger a defensive reaction in both Drosophila and mammals. Genetic data from both Drosophila and mice have defined components required for activation of Toll-like receptors and for the downstream pathways activated by the Toll-like receptors.},
	keywords = {Animals, Bacterial Infections, Drosophila, Drosophila Proteins, Immune System, Insect Proteins, Mammals, Membrane Glycoproteins, Models, Immunological, Mycoses, Receptors, Cell Surface, Receptors, Immunologic, Signal Transduction, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptors},
	issn = {0952-7915},
	author = {Anderson, K V}
}
