@article {162,
	title = {Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.},
	journal = {FEBS letters},
	volume = {582},
	year = {2008},
	month = {2008 Jul 23},
	pages = {2496-500},
	abstract = {In mammals, two inhibitory Smads (I-Smads), Smad6 and Smad7, play pivotal roles in negative regulation of TGF-beta family signaling. Smad7 ubiquitously inhibits TGF-beta family signaling, whereas Smad6 inhibits signaling from the ALK-3/6 subfamily in preference to that from the ALK-1/2 and ALK-4/5/7 subfamilies of TGF-beta family type I receptors. In Drosophila, only one I-Smad, Dad, has been identified. Here we examined inhibitory effects of Dad on type I receptors in Drosophila. Dad inhibited Saxophone (ALK-1/2 orthologue) and Thickveins (ALK-3/6 orthologue) but not Baboon (ALK-4/5/7 orthologue). The differential modes of action of I-Smads in mammals and Drosophila are discussed.},
	keywords = {Activin Receptors, Animals, DNA-Binding Proteins, Drosophila melanogaster, Drosophila Proteins, Humans, Phosphorylation, Protein-Serine-Threonine Kinases, Receptors, Cell Surface, Receptors, Transforming Growth Factor beta, Smad4 Protein, Transcription Factors},
	issn = {0014-5793},
	doi = {10.1016/j.febslet.2008.05.052},
	author = {Kamiya, Yuto and Miyazono, Kohei and Miyazawa, Keiji}
}
