@article {49, title = {Qualitative modelling of regulated metabolic pathways: application to the tryptophan biosynthesis in E.coli.}, journal = {Bioinformatics (Oxford, England)}, volume = {21 Suppl 2}, year = {2005}, month = {2005 Sep 1}, pages = {ii190-6}, abstract = {The integrated dynamical modelling of mixed metabolic/genetic networks constitutes one of the challenges of systems biology. Furthermore, as most of available data about genetic and metabolic regulations are qualitative, there is a pressing need for rigorous qualitative mathematical approaches.}, keywords = {Computer Simulation, Escherichia coli, Escherichia coli Proteins, Gene Expression Regulation, Models, Biological, Neural Networks (Computer), Signal Transduction, Tryptophan}, issn = {1367-4811}, author = {Sim{\~a}o, E and Remy, E and Thieffry, D and Chaouiya, C} }