%0 Journal Article %J Cell %D 1996 %T Dual roles for patched in sequestering and transducing Hedgehog. %A Chen, Y %A Struhl, G %K Alleles %K Animals %K Animals, Genetically Modified %K Drosophila melanogaster %K Drosophila Proteins %K Gene Expression Regulation, Developmental %K Hedgehog Proteins %K Insect Hormones %K Insect Proteins %K Macromolecular Substances %K Membrane Proteins %K Models, Biological %K Multigene Family %K Proteins %K Receptors, Cell Surface %K Receptors, G-Protein-Coupled %K Signal Transduction %K Wing %N 3 %P 553-63 %V 87 %X Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc-Smo complex, and thereby induces Smo activity. Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement. %8 1996 Nov 1