%0 Journal Article %J Bioinformatics (Oxford, England) %D 2005 %T Qualitative modelling of regulated metabolic pathways: application to the tryptophan biosynthesis in E.coli. %A Simão, E %A Remy, E %A Thieffry, D %A Chaouiya, C %K Computer Simulation %K Escherichia coli %K Escherichia coli Proteins %K Gene Expression Regulation %K Models, Biological %K Neural Networks (Computer) %K Signal Transduction %K Tryptophan %P ii190-6 %V 21 Suppl 2 %X The integrated dynamical modelling of mixed metabolic/genetic networks constitutes one of the challenges of systems biology. Furthermore, as most of available data about genetic and metabolic regulations are qualitative, there is a pressing need for rigorous qualitative mathematical approaches. %8 2005 Sep 1