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The JAK/STAT pathway and Drosophila development.

TitleThe JAK/STAT pathway and Drosophila development.
Publication TypeJournal Article
Year of Publication2001
AuthorsLuo H, Dearolf CR
JournalBioEssays : news and reviews in molecular, cellular and developmental biology
Date Published2001 Dec
KeywordsAnimals, DNA-Binding Proteins, Drosophila, Drosophila Proteins, Extremities, Eye, Glycoproteins, Insect Proteins, Janus Kinases, Protein-Tyrosine Kinases, Sex Determination Processes, Signal Transduction, STAT Transcription Factors, Trans-Activators, Transcription Factors, Wing

The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling.

Alternate JournalBioessays

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