| Title | Running interference for hedgehog signaling. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Michelson AM |
| Journal | Science's STKE : signal transduction knowledge environment |
| Volume | 2003 |
| Issue | 192 |
| Pagination | PE30 |
| Date Published | 2003 Jul 22 |
| ISSN | 1525-8882 |
| Keywords | Animals, Drosophila Proteins, Hedgehog Proteins, Humans, RNA Interference, Signal Transduction |
| Abstract | The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in the Hh and Wingless (Wg) pathways, but also provide proof of principle for the development of high-throughput assays using RNAi techniques. |
| DOI | 10.1126/stke.2003.192.pe30 |
| Alternate Journal | Sci. STKE |