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Logical Modelling of Gene Regulatory Networks with GINsim.

TitleLogical Modelling of Gene Regulatory Networks with GINsim.
Publication TypeBook Chapter
Year of Publication2012
AuthorsChaouiya C, Naldi A, Thieffry D
Book TitleMethods in molecular biology (Clifton, N.J.)

Discrete mathematical formalisms are well adapted to model large biological networks, for which detailed kinetic data are scarce. This chapter introduces the reader to a well-established qualitative (logical) framework for the modelling of regulatory networks. Relying on GINsim, a software implementing this logical formalism, we guide the reader step by step towards the definition and the analysis of a simple model of the lysis-lysogeny decision in the bacteriophage λ.

AbbreviationMethods Mol. Biol.

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