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Logical analysis of the budding yeast cell cycle

TitleLogical analysis of the budding yeast cell cycle
Publication TypeJournal Article
Year of Publication2009
AuthorsIrons DJ
JournalJournal of theoretical biology
Date Published2009 Apr 21
KeywordsCell Cycle, Cell Cycle Proteins, Genes, Fungal, Models, Biological, Mutation, Phenotype, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins

The budding yeast Saccharomyces cerevisiae is a model organism that is commonly used to investigate control of the eukaryotic cell cycle. Moreover, because of the extensive experimental data on wild type and mutant phenotypes, it is also particularly suitable for mathematical modelling and analysis. Here, I present a new Boolean model of the budding yeast cell cycle. This model is consistent with a wide range of wild type and mutant phenotypes and shows remarkable robustness against perturbations, both to reaction times and the states of component genes/proteins. Because of its simple logical nature, the model is suitable for sub-network analysis, which can be used to identify a four node core regulatory circuit underlying cell cycle regulation. Sub-network analysis can also be used to identify key sub-dynamics that are essential for viable cell cycle control, as well as identifying the sub-dynamics that are most variable between different mutants.

Alternate JournalJ. Theor. Biol.

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