| Title | Dual activation of the Drosophila toll pathway by two pattern recognition receptors. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Gobert V, Gottar M, Matskevich AA, Rutschmann S, Royet J, Belvin M, Hoffmann JA, Ferrandon D |
| Journal | Science (New York, N.Y.) |
| Volume | 302 |
| Issue | 5653 |
| Pagination | 2126-30 |
| Date Published | 2003 Dec 19 |
| ISSN | 1095-9203 |
| Keywords | Animals, Carrier Proteins, DNA Transposable Elements, Drosophila, Drosophila Proteins, Gene Expression, Genes, Insect, Gram-Negative Bacteria, Gram-Positive Bacteria, Hemolymph, Hypocreales, Insect Proteins, Mutation, Phenotype, Receptors, Cell Surface, Serine Endopeptidases, Toll-Like Receptors |
| Abstract | The Toll-dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 (GNBP1) gene and leads to compromised survival of mutant flies after Gram-positive infections, but not after fungal or Gram-negative bacterial challenge. Our results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway. The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects. |
| DOI | 10.1126/science.1085432 |
| Alternate Journal | Science |