Title | Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria. |
Publication Type | Journal Article |
Year of Publication | 2004 |
Authors | Bischoff V, Vignal C, Boneca IG, Michel T, Hoffmann JA, Royet J |
Journal | Nature immunology |
Volume | 5 |
Issue | 11 |
Pagination | 1175-80 |
Date Published | 2004 Nov |
ISSN | 1529-2908 |
Keywords | Animals, Carrier Proteins, Drosophila, Drosophila Proteins, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Mutation, Mycoses, Receptors, Cell Surface, Staphylococcus aureus, Toll-Like Receptors |
Abstract | The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of-function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex. |
DOI | 10.1038/ni1123 |
Alternate Journal | Nat. Immunol. |