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Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.

TitleFunction of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria.
Publication TypeJournal Article
Year of Publication2004
AuthorsBischoff V, Vignal C, Boneca IG, Michel T, Hoffmann JA, Royet J
JournalNature immunology
Volume5
Issue11
Pagination1175-80
Date Published2004 Nov
ISSN1529-2908
KeywordsAnimals, Carrier Proteins, Drosophila, Drosophila Proteins, Gram-Positive Bacteria, Gram-Positive Bacterial Infections, Mutation, Mycoses, Receptors, Cell Surface, Staphylococcus aureus, Toll-Like Receptors
Abstract

The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of-function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex.

DOI10.1038/ni1123
Alternate JournalNat. Immunol.


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