| Title | Dual roles for patched in sequestering and transducing Hedgehog. |
| Publication Type | Journal Article |
| Year of Publication | 1996 |
| Authors | Chen Y, Struhl G |
| Journal | Cell |
| Volume | 87 |
| Issue | 3 |
| Pagination | 553-63 |
| Date Published | 1996 Nov 1 |
| ISSN | 0092-8674 |
| Keywords | Alleles, Animals, Animals, Genetically Modified, Drosophila melanogaster, Drosophila Proteins, Gene Expression Regulation, Developmental, Hedgehog Proteins, Insect Hormones, Insect Proteins, Macromolecular Substances, Membrane Proteins, Models, Biological, Multigene Family, Proteins, Receptors, Cell Surface, Receptors, G-Protein-Coupled, Signal Transduction, Wing |
| Abstract | Secreted proteins of the Hedgehog (Hh) family have diverse organizing roles in animal development. Recently, a serpentine protein Smoothened (Smo) has been proposed as a Hh receptor. Here, we present evidence that implicates another multiple-pass transmembrane protein, Patched (Ptc), in Hh reception and suggests a novel signal transduction mechanism in which Hh binds to Ptc, or a Ptc-Smo complex, and thereby induces Smo activity. Our results also show that Ptc limits the range of Hh action; we provide evidence that high levels of Ptc induced by Hh serve to sequester any free Hh and therefore create a barrier to its further movement. |
| Alternate Journal | Cell |