Title | Toll signaling pathways in the innate immune response. |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Anderson KV |
Journal | Current opinion in immunology |
Volume | 12 |
Issue | 1 |
Pagination | 13-9 |
Date Published | 2000 Feb |
ISSN | 0952-7915 |
Keywords | Animals, Bacterial Infections, Drosophila, Drosophila Proteins, Immune System, Insect Proteins, Mammals, Membrane Glycoproteins, Models, Immunological, Mycoses, Receptors, Cell Surface, Receptors, Immunologic, Signal Transduction, Toll-Like Receptor 4, Toll-Like Receptor 5, Toll-Like Receptors |
Abstract | The Toll signaling pathway, which is required for the establishment of the dorsal-ventral axis in Drosophila embryos, plays an important role in the response of larval and adult Drosophila to microbial infections. Recent genetic evidence has shown that a mammalian Toll-like receptor, mouse Tlr4, is the signal transducing receptor activated by bacterial lipopolysaccharide. Thus, Toll-like receptors appear to detect a variety of microbial components and to trigger a defensive reaction in both Drosophila and mammals. Genetic data from both Drosophila and mice have defined components required for activation of Toll-like receptors and for the downstream pathways activated by the Toll-like receptors. |
Alternate Journal | Curr. Opin. Immunol. |