| Title | Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Kamiya Y, Miyazono K, Miyazawa K |
| Journal | FEBS letters |
| Volume | 582 |
| Issue | 17 |
| Pagination | 2496-500 |
| Date Published | 2008 Jul 23 |
| ISSN | 0014-5793 |
| Keywords | Activin Receptors, Animals, DNA-Binding Proteins, Drosophila melanogaster, Drosophila Proteins, Humans, Phosphorylation, Protein-Serine-Threonine Kinases, Receptors, Cell Surface, Receptors, Transforming Growth Factor beta, Smad4 Protein, Transcription Factors |
| Abstract | In mammals, two inhibitory Smads (I-Smads), Smad6 and Smad7, play pivotal roles in negative regulation of TGF-beta family signaling. Smad7 ubiquitously inhibits TGF-beta family signaling, whereas Smad6 inhibits signaling from the ALK-3/6 subfamily in preference to that from the ALK-1/2 and ALK-4/5/7 subfamilies of TGF-beta family type I receptors. In Drosophila, only one I-Smad, Dad, has been identified. Here we examined inhibitory effects of Dad on type I receptors in Drosophila. Dad inhibited Saxophone (ALK-1/2 orthologue) and Thickveins (ALK-3/6 orthologue) but not Baboon (ALK-4/5/7 orthologue). The differential modes of action of I-Smads in mammals and Drosophila are discussed. |
| DOI | 10.1016/j.febslet.2008.05.052 |
| Alternate Journal | FEBS Lett. |