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Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.

TitleSpecificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.
Publication TypeJournal Article
Year of Publication2008
AuthorsKamiya Y, Miyazono K, Miyazawa K
JournalFEBS letters
Volume582
Issue17
Pagination2496-500
Date Published2008 Jul 23
ISSN0014-5793
KeywordsActivin Receptors, Animals, DNA-Binding Proteins, Drosophila melanogaster, Drosophila Proteins, Humans, Phosphorylation, Protein-Serine-Threonine Kinases, Receptors, Cell Surface, Receptors, Transforming Growth Factor beta, Smad4 Protein, Transcription Factors
Abstract

In mammals, two inhibitory Smads (I-Smads), Smad6 and Smad7, play pivotal roles in negative regulation of TGF-beta family signaling. Smad7 ubiquitously inhibits TGF-beta family signaling, whereas Smad6 inhibits signaling from the ALK-3/6 subfamily in preference to that from the ALK-1/2 and ALK-4/5/7 subfamilies of TGF-beta family type I receptors. In Drosophila, only one I-Smad, Dad, has been identified. Here we examined inhibitory effects of Dad on type I receptors in Drosophila. Dad inhibited Saxophone (ALK-1/2 orthologue) and Thickveins (ALK-3/6 orthologue) but not Baboon (ALK-4/5/7 orthologue). The differential modes of action of I-Smads in mammals and Drosophila are discussed.

DOI10.1016/j.febslet.2008.05.052
Alternate JournalFEBS Lett.


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