Mast cell activation

Summary:

Based on an exhaustive curation of the existing literature and using the software CellDesigner, we have built and annotated a comprehensive molecular map for the FceRI and FcgRIIb signalling pathways, which play a key role in mast cell activation in mammals. Using this map and the logical modelling software GINsim, we have derived a logical model recapitulating the most salient features of mast cell activation. This model can be used to explore the dynamical properties of the system and its responses to different stimuli, in normal or mutant conditions. For more details, see [1].

References

Niarakis A, Bounab Y, Grieco L, Roncagalli R, Hesse A-M, Garin J, Malissen B, Daëron M, Thieffry D. 2014. Computational modeling of the main signaling pathways involved in mast cell activation. Current topics in microbiology and immunology. 382:69-93.

Curation

Submitter:

Denis Thieffry

Supporting Paper :

Computational modeling of the main signaling pathways involved in mast cell activation

Model metadata

Model file(s):

Mast_cell_activation_Annotated_19oct2014.zginml

Description:

This model file should be open with the software GINsim, version 2.9.2 or later. This file includes the logical rules associated with each component, along with annotations and links to MedLine, RefGene, HGNC and UniProt databases. The model further includes different parameterisation settings enabling the reproductions of all simulations mentioned in the manuscript.