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Budding yeast cell cycle (Orlando et al. 2008)


This model is a direct transcription of the Boolean model published by Orlando et al. [1]. Synchronous simulation of this model yields a cyclic attractor gathering most trajectories in the state transition graph, which is robust to parameter choice, as reported in [1]. However, asynchronous simulations all lead to a stable state with all variables OFF, whatever the parameter set proposed by the authors, indicating that the oscillations observed in the synchronous simulations may not be sustained. See [2] for more details.


Adrien Fauré (C. Chaouiya)

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