Summary:
This logical model accounts for the differentiation of monocytes into monocyte-derived dendritic cells (moDCs) and macrophages. It recapitulates the main established facts regarding wild-type differentiation of monocytes and macrophages in the presence of CSF2 and/or IL4, as well as the impact of various documented mutations. This model integrates documented regulatory interactions, together with novel interactions predicted from public transcriptomic and epigenomic data, enabling to validate in silico various novel transcriptional regulatory links presumably involved in this differentiation process.