Summary:
The low response to infection in neonatal T cells contributes to a high incidence of morbidity and mortality. Here we evaluated the effect of the cytoplasmic and mitochondrial levels of Reactive Oxygen Species (ROS) of neonatal CD8+T cells on their low activation. This model captures the interplay between antigen recognition with ROS and metabolic status in T cell responses. This model displays alternative stable states, which corresponds to different cell fates, i.e. quiescent, activated and anergic, depending on ROS status.
The associated notebook can be loaded using the CoLoMoTo notebook docker image (see http://www.colomoto.org/notebook).